Mohamed Thabet 'Sarokh' scored in the sixth minute to lead Arab Champions League finalists, Enppi to a 1-0 victory over Olympic.
In other matches, Abdul-Salam Nagah notched a brace to help Harras Al Hodoud register a 2-0 victory against Asyut Petroleum.
Nagah snatched the lead early in the 10th minute before adding the second in the 73rd minute.
Newly-promoted Petrojet also made a winning start thanks to a 3-2 away win over Al-Gaish.
Gomaa Mashhor's penalty for Al-Gaish two minutes after the interval cancelled out Ahmed Shaaban's opener in the 18th minute.
Mohamed Eid put Al-Gaish ahead in the 71st minute before two strikes by Mahmoud Abdul-Hakim and Walid Soliman in the last 10 minutes sealed the victory for Petrojet.
Arab Contractors were held a 1-1 home draw with Ittihad Alexandria.
Reda Ragab put Ittihad ahead in the 33rd minute before Minusu Buba equalized for the hosts in the 69th minute.
Results| Ennepi | 1-0 | Olympic |
Harras Al Hodoud | 2-0 | Asyut Petroleum |
Al-Gaish | 2-3 | Petrojet |
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